Why the study?
The effect of temperature fluctuation on action potential patterns in a network of electrically coupled myocardial cells was investigated.
Temperature fluctuations promote wave localization and mode transition in cardiac electrical activities through modulational instability, providing biophysical insights into mechanisms of sudden heart disorders.
Based on the improved FitzHugh-Nagumo myocardial model driven by a constant external current, the effect of temperature fluctuation in a network of electrically coupled myocardial cells are investigated through analytical and numerical computations. Through the technique of multiple scale expansion, we successfully reduced the complex nonlinear system of equations to a more tractable and solvable nonlinear amplitude equation on which the analysis of linear stability is performed. Interestingly from this analysis, a plot of critical amplitude of action potential versus wave number revealed the growth rate of modulational instability (MI) is an increasing function of the thermoelectric couplings; [Formula: see text] and [Formula: see text], under fixed conditions of nonlinear electrical couplings. In order to verify our analytical predictions through the study the long-time evolution of the modulated cardiac impulses, numerical computation is finally carried out. Numerical experiment revealed the existence of localized coherent structures with some recognized features of synchronization. Through the mechanism of MI, changes in thermoelectrical couplings promote wave localization and mode transition in electrical activities in the cell lattice. Results could provide new insights in understanding the underlying mechanism of the manifestation of sudden heart disorder subjected to heavily temperature fluctuation.
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Takembo et al. (2020) studied Cardiac electrical activity (computational model). Temperature fluctuation (thermoelectric couplings) vs. Baseline temperature parameters was evaluated on Modulational instability and localized wave patterns.
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