Review highlights kisspeptin and DLK1 as biomarkers in girls with central precocious puberty, suggesting their utility for monitoring therapy.
Kisspeptin and delta-like 1 homolog (DLK1) are neuropeptides that reportedly play an important role in pubertal timing by activating and inhibiting the hypothalamic-pituitary-gonadal axis, respectively. Consequently, serum kisspeptin and DLK1 levels may be novel biomarkers for differentiating between central precocious puberty (CPP) and premature thelarche (PT) in girls and used to monitor CPP treatment.
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Onsoi et al. (2024) studied this question.
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