Primary central nervous system lymphoma (PCNSL) involving the corpus callosum is rare and diagnostically challenging. We report a 63-year-old female with cognitive impairment, and personality changes. MRI showed a hyperintense lesion in the corpus callosum, and biopsy confirmed diffuse large B-cell lymphoma (DLBCL). This case highlights the importance of considering PCNSL in differential diagnoses of corpus callosum lesions and underscores the necessity for prompt, aggressive treatment despite a guarded prognosis.
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Lemtouni et al. (2024) studied this question.
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