We are what we eat: macrophages and efferocytosis

Kyle T. Cunningham; Rick M. Maizels

doi:10.1016/j.pt.2024.05.004

May 20, 2024Trends in ParasitologyOpen Access

We are what we eat: macrophages and efferocytosis

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Key Points

Engulfment and clearance of dying cells through efferocytosis drives distinct functional changes in liver macrophages, which directly regulate tissue egg burdens during infection.
Assessment of helminth infection demonstrates that clearance phenotypes depend on signaling through Axl and MerTK receptors, altering host responses to Schistosoma mansoni.
Targeting efferocytosis pathways in liver macrophages highlights novel mechanisms of immune regulation during parasitic disease—murine model; further preclinical work needed.

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Preclinical study reveals dying cell clearance alters liver macrophages during Schistosoma mansoni infection, indicating that Axl and MerTK receptors regulate helminth egg burden.

Abstract

Liebold et al. recently revealed how the identity of dying cells drives distinct changes to the macrophages which engulf and clear them, a process known as efferocytosis. During infection with the helminth Schistosoma mansoni, liver macrophages recapitulate these phenotypes, mediated by Axl/MerTK receptors and regulating egg burdens.

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Cunningham et al. (2024) studied this question.

synapsesocial.com/papers/68e694aeb6db64358761ac05 https://doi.org/10.1016/j.pt.2024.05.004

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We are what we eat: macrophages and efferocytosis

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We are what we eat: macrophages and efferocytosis

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