Usefulness of Colchicine to Reduce Peri-Procedural Myocardial Injury in Patients Who Underwent Primary Percutaneous Coronary Intervention

Background: Percutaneous coronary intervention (PCI) is an invasive, yet non-operative procedure designed to alleviate the constriction of the coronary artery. PCI is indicated for various clinical scenarios in the management of coronary artery disease (CAD).Aim: To study the effect of colchicine given pre-PCI on post-PCI-induced myocardial injury within 24 hours of the index PCI procedure among patients with ACS who underwent primary PCI.Methods: This prospective interventional study included patients with a diagnosis of acute coronary syndrome who underwent primary PCI and were divided into two groups: group 1 (patient group) included patients who received colchicine, and group 2 (control group) included patients who received placebo. Laboratory investigations included cardiac biomarkers, immediately pre- and 24 hours post-PCI, C-reactive protein and interleukin-6 and kidney function tests including urea and creatinine. Transthoracic echocardiography was done on every patient.Results: The current study revealed no significant variations between the colchicine and placebo groups regarding the cardiac biomarkers. After PCI, the mean CRP levels and mean IL6 levels were significantly lower in the colchicine group compared to the placebo group. The present study found no significant differences in LVEF, LVEDV, LVESD, or RWMA between the two groups. No significant differences in the proportions of TIMI 2 and TIMI 3 flow between the two groups were found. IL-6 and CRP showed significant positive correlations with each other before and after PCI.