Low Frequency Tibial Neuromodulation Increases Voiding Activity - A Computational Model

Despite its clinical adoption, there remains a lack of understanding about how tibial nerve stimulation (TNS) improves lower urinary tract symptoms. Current evidence indicates that TNS ameliorates overactive bladder by the inhibition of micturition related activity in the brainstem and spinal cord. We present a detailed computational model and demonstrate that TNS can also induce excitatory effects via brainstem specific activity, proposing non-invasive neuromodulation as a treatment for urinary retention.