1q amplification and PHF19 expressing high-risk cells are associated with relapsed/refractory multiple myeloma

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation2019 · 83 citations
2. 2PHF19 inhibition increases IMiDs sensitivity by epigenetically regulating IRF4 and MYC in multiple myeloma2025
3. 3Single-cell profiling uncovers PTPRG-driven stemness in malignant plasma cells and signatures of treatment failure in multiple myeloma2025
4. 4Integrative analysis of the genomic and transcriptomic landscape of double-refractory multiple myeloma2020 · 81 citations
5. 5Targeting the origins of multiple myeloma along hematopoietic stem cell lymphoid lineage differentiation2025