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November 19, 2025Science Translational Medicine

Targeting the origins of multiple myeloma along hematopoietic stem cell lymphoid lineage differentiation

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Authors

JGJiaojiao GuoYLYaru LiZYZhiling Yan

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Overview

This research demonstrates therapeutic strategies linked to hematopoietic stem cells in multiple myeloma, highlighting their role in disease transformation.

Key Points

  • The study aims to understand the mechanisms of malignant transformation in multiple myeloma-initiating cells.
  • Utilized single-cell sequencing
  • Conducted genetic tracer analysis at various developmental stages
  • Identified differentiation abnormalities in patients with multiple myeloma
  • Found that chromosome 1q amplification originates from specific B cell subgroups
  • Confirmed that 1q Amp enhances B cell proliferation and plasma cell differentiation
  • Showed safety and efficacy of FCRL5 CAR T cells in relapsed/refractory multiple myeloma patients

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/6924f095c0ce034ddc350be8https://doi.org/10.1126/scitranslmed.adu0114
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1On the cellular origins of multiple myeloma2025
  2. 2Deciphering the cellular hierarchy of multiple myeloma uncovers a therapeutically exploitable EP300/TBX2 axis in LILRB4+ myeloma-initiating cells2025
  3. 3Single-cell sequencing analysis of multiple myeloma heterogeneity and identification of new theranostic targets2024
  4. 4Phylogenetic reconstruction reveals early divergence and late expansion of focal lesions in multiple myeloma2025
  5. 5Genomic Insights into Tumorigenesis in Newly Diagnosed Multiple Myeloma2025