May 15, 2024PLoS ONEOpen Access

Carbon monoxide as a cellular protective agent in a swine model of cardiac arrest protocol

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Experimental protocol reports cellular protection from low-dose carbon monoxide in swine cardiac arrest, suggesting improved neurologic recovery.

The protocol aims to investigate the cellular protective effects of low-dose carbon monoxide, addressing severe post-resuscitation tissue injury following cardiac arrest.
Planned primary outcomes focus on changes in cerebral metabolism and mitochondrial function, evaluated after return of spontaneous circulation during therapeutic delivery.
Trial protocol combines an innovative multi-modal diagnostic platform with swine models of cardiac arrest, testing carbon monoxide generated physiologically via heme oxygenase.
Therapy may enhance neurologic recovery beyond supportive care and targeted temperature management, though results are pending in this swine model before clinical translation.

Greenwood et al. (2024) studied this question.

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Experimental protocol reports cellular protection from low-dose carbon monoxide in swine cardiac arrest, suggesting improved neurologic recovery.