FIGURE 1 from Mutant RAS-driven Secretome Causes Skeletal Muscle Defects in Breast Cancer

Tumor subtypes differentially affect skeletal muscle function in mice with PDXs. A, Growth rate of PDXs in NSG mice. B, Histology of PDXs confirming their molecular subtype. C, Impaired rotarod performance of mice with PDXs across all tumor subtypes. D, Differential impact of tumors by subtype on grip strength of mice with PDXs. Mice with TNBC tumors had severe loss of grip strength. E, Loss of grip strength was improved by Curaxin (CBL0137) treatment in nude mice with tumors from MDA-MB-436 cells. F, Impaired rotarod performance was ameliorated by Curaxin (CBL0137) in nude mice with tumors from MDA-MB-436 cells.