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Abstract In this paper, the evaluation of a boron‐doped ultrananocrystalline diamond (BD‐UNCD) electrode for the determination of ibuprofen (IBU) in pharmaceutical formulations using batch‐injection analysis with amperometric detection (BIA‐AD) is presented. The BD‐UNCD electrode was characterized by Raman spectroscopy and the electrochemical measurements were carried out before and after anodic pretreatment. An improved electrochemical response for IBU oxidation was observed using BD‐UNCD as compared to commercial boron‐doped diamond electrode. The optimized method based on the BIA‐AD system was carried out by using 2.0 V as the detection potential, a dispensing rate of 211.9 μL s −1 , and an injection volume of 40 μL in an electrochemical cell containing 30.0 mL of 1.0 mol L −1 HClO 4 as the supporting electrolyte. The proposed method provided an analytical curve within a linear dynamic range from 1.84 to 20.0 μmol L −1 (R 2 =0.9967) and a limit of detection of 0.55 μmol L −1 . The intra‐day (n=10) and inter‐day (n=2) precisions for IBU concentrations of 5.0 and 10.0 μmol L −1 assessed as relative standard deviation (%RSD) ranged from 2.65 to 5.84 %. The accuracy of the method was assessed through the determination of IBU in pharmaceutical samples (tablets and solutions), yielding results that were consistent with those obtained through the comparative method (HPLC‐DAD).
Prete et al. (Tue,) studied this question.