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May 14, 2024Open Access

FIGURE 7 from Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas

Ayako Nakashoji Naoki Haratake Atrayee Bhattacharya Weipu Mao Kangjie Xu Keyi Wang Tatsuaki Daimon Hiroki Ozawa Keisuke Shigeta Atsushi Fushimi Nami Yamashita Yoshihiro Morimoto Mototsugu Shimokawa Shin Saito Ann Marie Egloff Ravindra Uppaluri Mark D. Long Donald Küfe

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Abstract

Single-cell profiling of the expression of MUC1 and related genes in HNSCC. A–C, UMAP representation of total cells analyzed from the GSE118389 dataset of HPV-negative/HPV-positive HNSCC samples (A), GSE118389 dataset of HPV-negative samples (B), and GSE118389 dataset of HPV-positive samples (C) (left). Distributions of MUC1 expression in individual cells (middle). MUC1 expression in individual cells in each cell type (right). D, Model depicting the current findings that MUC1-C integrates activation of STAT1, IFN type I/II signaling and ISG expression with regulation of ∆Np63, SOX2, and NOTCH3 in driving the HNSCC CSC state that promotes DNA damage resistance and immune evasion.

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Cite This Study

Nakashoji et al. (2024) studied this question.

synapsesocial.com/papers/68e6a4e2b6db64358762795c https://doi.org/10.1158/2767-9764.25817977

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S7 from Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas2024
2Data from Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas2024
3IDENTIFICATION OF MUC1-C AS A TARGET FOR SUPPRESSING PROGRESSION OF HEAD AND NECK SQUAMOUS CELL CARCINOMAS2024 · 5 citations
4Figure S2 from Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas2024
5Figure S1 from Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas2024

More related papers

FIGURE 1 from Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas2024
Figure S4 from Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas2024
Figure S3 from Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas2024