Recombinant prourokinase in the treatment of postoperative endophthalmitis

Purpose. To determine the effectiveness of prourokinase in the treatment of acute postoperative endophthalmitis. Material and methods. The study included 5 patients with acute endophthalmitis after cataract surgery. Symptoms of endophthalmitis appeared on the 3rd day after surgery in 3 patients, on the 4th in 2 patients. All patients underwent vitrectomy on the day of presentation without inducing posterior detachment of the hyaloid membrane with intravitreal administration of a combination of antibiotic and prourokinase at the end of the operation. Results.On the first day after surgery, all patients had severe inflammatory manifestations, which completely disappeared by day 7. Maximum corrected visual acuity after 1 month was: 0.7 in 1 patient, 0.8 in 1 patient, 1.0 in 3 patients. Conclusion.The use of recombinant prourokinase in combination with intravitreal antibiotics and vitrectomy demonstrated high functional results without complications in the early postoperative period.