Abstract The global healthcare market increasingly demands affordable molecular diagnostics for field testing. We introduce a Lab-on-paper (LOP) platform, integrating isothermal amplification with a specially designed paper strip for molecular testing through automated microfluidics process, to meet these unmet needs in point-of-care testing technology. The LOP system has been designed for rapid, cost-effective, and highly sensitive detection, using USB-powered thermal management with a wax valve mechanism. It provides an accessible solution for rapid and accurate detection of various microorganisms, proving particularly beneficial for point-of-care testing in resource-limited environments. Experiments in this study have demonstrated efficacy of the LOP platform in colorimetric detection of foodborne pathogens in spiked samples, identifying Vibrio vulnificus in oysters and Salmonella typhimurium in meat at as few as 60 and 120 CFU per reaction respectively. Portability, ease of use, and affordability of the LOP make it a promising alternative for diverse diagnostic needs, including infectious disease monitoring and ensuring food safety.
No takes yet. Share an insight, caveat, or question.
Kim et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: