This synthesis reveals tetrasubstituted 2-aminothiophenes via a multi-component reaction using ketene dithioacetals and secondary amines, suggesting new pharmacological applications.
We have reported the synthesis of pharmacologically valuable tetrasubstituted 2-aminothiophenes through a multi-component reaction using ketene dithioacetals, secondary amines, and thioglycolates in the presence of a catalytic amount of triethylamine...
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Chahal et al. (2025) studied this question.
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