Figure S2 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression

Naveen Kumar Tangudu; Raquel Buj; Hui Wang; Jiefei Wang; Aidan R. Cole; Apoorva Uboveja; Richard Fang; Amandine Amalric; Baixue Yang; Adam Chatoff; Claudia V. Crispim; Peter Sajjakulnukit; Maureen A. Lyons; Kristine Cooper; Nadine Hempel; Costas A. Lyssiotis; Uma Chandran; Nathaniel W. Snyder; Katherine M. Aird

doi:10.1158/2767-9764.25738380.v1

Abstract

Knockdown or knockout of Cdkn2a in mouse melanoma cell lines increases sensitivity to multiple anti-folates but not to de novo pyrimidine synthesis; Knockdown of RB1 does not recapitulate the anti-folate response exhibited by shp16 cells. Related to Figure 3.

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Tangudu et al. (2024) studied this question.

synapsesocial.com/papers/68e6bd48b6db64358763de69 https://doi.org/10.1158/2767-9764.25738380.v1

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Figure S2 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression

Abstract

Discussion

Cite This Study

Figure S2 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression

Abstract

Discussion

Cite This Study

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