Figure S3 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression

Naveen Kumar Tangudu; Raquel Buj; Hui Wang; Jiefei Wang; Aidan R. Cole; Apoorva Uboveja; Richard Fang; Amandine Amalric; Baixue Yang; Adam Chatoff; Claudia V. Crispim; Peter Sajjakulnukit; Maureen A. Lyons; Kristine Cooper; Nadine Hempel; Costas A. Lyssiotis; Uma Chandran; Nathaniel W. Snyder; Katherine M. Aird

doi:10.1158/2767-9764.25738377

Abstract

Anti-folates induce death and increased DNA damage foci in shCdkn2a cells; shp16 cells do not mount a robust senescence-associated secretory phenotype (SASP) in response to Palbociclib; anti-proliferative effects of anti-folates are longer-lived than palbociclib; and folate transporters are upregulated in shp16/shCdk2na cells. Related to Figure 4.

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Tangudu et al. (2024) studied this question.

synapsesocial.com/papers/68e6bd48b6db64358763de73 https://doi.org/10.1158/2767-9764.25738377

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Figure S3 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression

Abstract

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Cite This Study

Figure S3 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression

Abstract

Discussion

Cite This Study

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