FIGURE 6 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression

De novo purine synthesis and one carbon metabolism genes are associated with worse overall survival in metastatic melanomas. Data from TCGA Skin Cutaneous Melanoma PanCancer Atlas (367 metastatic melanomas). Raw data can be found in Supplementary Table S8. A,De novo purine synthesis and one carbon metabolism genes in TCGA metastatic melanoma samples. Red indicates increased mRNA expression. Blue indicates decreased mRNA expression. Overall survival probability of patients with alterations in de novo purine synthesis and one carbon metabolism genes (B), de novo pyrimidine genes (C), overall nucleotide biosynthesis genes (D), and nucleotide salvage genes (E). log-rank P-value and 95% confidence interval.