Figure S1 from Darolutamide Added to Docetaxel Augments Antitumor Effect in Models of Prostate Cancer through Cell Cycle Arrest at the G₁–S Transition

Combination of docetaxel and darolutamide in VCaP PDXOs A: Dose-response curve with mean normalized viability (+/- SEM) of three separate experiments with technical sextuplicates. Curves were interpolated by non-linear regression analysis and used to determine absolute IC50 value. B: Logarithmic Combination Index (CI) plot for the combination of docetaxel and darolutamide, identifying synergistic (log(CI) < 0), additive (log(CI) = 0) or antagonistic (log(CI) > 0) effects. Fa: fractional effect. The combination index and corresponding degree of synergism or antagonism is indicated for each combination.(18)