Metabolite heatmap between Cohorts 1 and 2. The left panels (A, C) were obtained in the negative polarity mode, and the right panels (B, D) were obtained in the positive polarity mode. Each row in the graph represents one differential metabolite, and each column represents a set of samples. Red represents significant upregulation, blue represents significant downregulation, color shades indicate the degree of upper downregulation, and metabolites with close expression patterns are clustered under the same cluster on the left.
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Xu et al. (2024) studied this question.
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