May 2, 2024Cancer Research

Abstract PO2-01-07: Real-world efficacy of dual HER2-blockade in combination with anthracycline-containing and anthracycline-free neoadjuvant treatment in early breast cancer (BC)

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Authors

BCBeatriz Alonso de CastroUniversidade da Coruña CRCristina ReboredoComplexo Hospitalario Universitario A Coruña LCLourdes CalvoComplexo Hospitalario Universitario A Coruña

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Implication

Retrospective analysis shows similar efficacy of dual HER2-blockade with anthracyclines and platinum in early breast cancer, indicating favorable cardiac safety.

Key Points

Pathological complete response rate reached 50.6% among patients treated with dual HER2-blockade and chemotherapy.
Among hormonal receptor negative tumors, the tpCR rate was significantly higher at 73.3%, compared to 36.2% for positive cases.
Retrospective observational analysis included 154 women with HER2 positive early breast cancer treated between 2015 and 2022 at a single university hospital in Spain. Cardiotoxicity rates were low, suggesting dual HER2-blockade with chemotherapy may have favorable cardiac safety in real-world settings.

Cite This Study

Castro et al. (2024) studied this question.

synapsesocial.com/papers/68e6bea5b6db64358763eb06 https://doi.org/10.1158/1538-7445.sabcs23-po2-01-07

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Implication

Retrospective analysis shows similar efficacy of dual HER2-blockade with anthracyclines and platinum in early breast cancer, indicating favorable cardiac safety.

Abstract PO2-01-07: Real-world efficacy of dual HER2-blockade in combination with anthracycline-containing and anthracycline-free neoadjuvant treatment in early breast cancer (BC)

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract PO2-01-07: Real-world efficacy of dual HER2-blockade in combination with anthracycline-containing and anthracycline-free neoadjuvant treatment in early breast cancer (BC)

Discussion

Member takes

Implication

Key Points

Cite This Study

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