May 1, 2024CellOpen Access

Mitochondria at the crossroads of health and disease

View Full Paper

Ask AI

Bookmark

Authors

ASAnu SuomalainenUniversity of Helsinki JNJodi NunnariF5 Networks (United States)

Discussion

Member takes

Implication

Review reveals how dynamic mitochondrial tuning coordinates cellular metabolism, suggesting central roles in health maintenance, aging, and disease pathogenesis across tissues.

Key Points

Mitochondria govern cellular function by dynamically coordinating catabolic metabolism and anabolic metabolism in response to shifting tissue-specific needs for energy and growth.
Review analysis examines how intrinsic and extrinsic stresses trigger metabolic signaling within cells and across distal tissues to modulate organismal function and cellular renewal.
Understanding mitochondrial tuning across tissues highlights pathways in human aging and disease pathogenesis, supporting targeted therapeutic strategies for metabolic disruption.

Cite This Study

Suomalainen et al. (2024) studied this question.

synapsesocial.com/papers/68e6c02bb6db64358763f445 https://doi.org/10.1016/j.cell.2024.04.037

View Full Paper

Ask AI

Bookmark

Implication

Review reveals how dynamic mitochondrial tuning coordinates cellular metabolism, suggesting central roles in health maintenance, aging, and disease pathogenesis across tissues.

Mitochondria at the crossroads of health and disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Mitochondria at the crossroads of health and disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider