Supplementary figure S1 from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

Tetsuo Tani; Haritha Mathsyaraja; Marco Campisi; Ze-Hua Li; Koji Haratani; Caroline G. Fahey; Keiichi Ota; Navin R. Mahadevan; Yingxiao Shi; Shin Saito; Kei Mizuno; Tran C. Thai; Nobunari Sasaki; Mizuki Homme; Choudhury Fabliha B. Yusuf; Adam Kashishian; Jipsa Panchal; Min Wang; Benjamin Wolf; Thanh U. Barbie; Cloud P. Paweletz; Prafulla C. Gokhale; David Liu; Ravindra Uppaluri; Shunsuke Kitajima; Jennifer Cain; David A. Barbie

doi:10.1158/2159-8290.25729047.v1

Key Points

Inactivation of TREX1 unleashes STING–interferon signaling within cancer cells, thereby promoting protective antitumor immunity across experimental models.
Analysis of supplementary data provides supporting experimental images and assays, detailing cancer cell responses linked to primary figure evaluations.
Modulation of TREX1 highlights potential therapeutic avenues for activating innate immune signaling, though extended in vivo validation remains warranted.

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Implication

Experimental study demonstrates STING–interferon signaling induction following TREX1 inactivation in cancer cells, suggesting potential strategies to enhance antitumor immune defense.

Abstract

Supplementary figureS1 shows the figures related to Figure 1.

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Tani et al. (2024) studied this question.

synapsesocial.com/papers/68e6c4bab6db643587643a87 https://doi.org/10.1158/2159-8290.25729047.v1

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Supplementary figure S1 from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary figure S1 from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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