Supplementary figure S2 from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

Key Points

Inactivation of TREX1 unleashes STING-interferon signaling within cancer cells, which acts to stimulate robust antitumor immunity against malignant targets.
Supplementary data document molecular responses tied to TREX1 loss, detailing cellular changes in STING pathway markers alongside Figure 2 presentations.
Targeting TREX1 to restore STING-interferon signaling may enhance antitumor immunity, offering therapeutic promise for overcoming cancer immune evasion.

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Experimental analysis reveals TREX1 inactivation unleashes STING-interferon signaling in cancer cells, indicating enhanced antitumor immunity.

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Tani et al. (2024) studied this question.

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