May 1, 2024Open Access

Supplementary figure S3 from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

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Inactivation of TREX1 unleashes cancer cell STING–interferon signaling, which subsequently promotes antitumor immunity within the targeted tumor microenvironment.
Supplementary figure S3 provides supporting visual data directly related to Figure 3, documenting molecular responses linked to TREX1 loss across experimental panels.
These supplementary data clarify how loss of TREX1 triggers STING signaling pathways, highlighting potential therapeutic avenues despite remaining preclinical bounds.

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Implication

Experimental analysis demonstrates enhanced STING-interferon signaling following TREX1 loss in cancer models, highlighting mechanisms of antitumor immunity.

Abstract

Supplementary figureS3 shows the figures related to Figure 3.

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Cite This Study

Tani et al. (2024) studied this question.

synapsesocial.com/papers/68e6c4bab6db643587643a4b https://doi.org/10.1158/2159-8290.25729041.v1

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Implication

Experimental analysis demonstrates enhanced STING-interferon signaling following TREX1 loss in cancer models, highlighting mechanisms of antitumor immunity.

Abstract

Supplementary figureS3 shows the figures related to Figure 3.

Supplementary figure S3 from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

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No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary figure S3 from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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