Supplementary figure S4 from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

Tetsuo Tani; Haritha Mathsyaraja; Marco Campisi; Ze-Hua Li; Koji Haratani; Caroline G. Fahey; Keiichi Ota; Navin R. Mahadevan; Yingxiao Shi; Shin Saito; Kei Mizuno; Tran C. Thai; Nobunari Sasaki; Mizuki Homme; Choudhury Fabliha B. Yusuf; Adam Kashishian; Jipsa Panchal; Min Wang; Benjamin Wolf; Thanh U. Barbie; Cloud P. Paweletz; Prafulla C. Gokhale; David Liu; Ravindra Uppaluri; Shunsuke Kitajima; Jennifer Cain; David A. Barbie

doi:10.1158/2159-8290.25729038

Key Points

Inactivation of TREX1 unleashes cancer cell STING–interferon signaling, and this functional activation promotes antitumor immunity across treated experimental models.
Experimental analysis provides supplementary data linked to Figure 4, clarifying the cellular role of TREX1 inactivation within tumor cells.
Targeting TREX1 may enhance antitumor immunity through endogenous interferon signaling pathways—preclinical cell model; further validation is warranted.

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Implication

Experimental analysis reveals TREX1 inactivation unleashes STING–interferon signaling in cancer cells, highlighting potential avenues to promote antitumor immunity.

Abstract

Supplementary figureS4 shows the figures related to Figure 4.

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Tani et al. (2024) studied this question.

synapsesocial.com/papers/68e6c4b3b6db643587643641 https://doi.org/10.1158/2159-8290.25729038

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Supplementary figure S4 from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

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Implication

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Cite This Study

Supplementary figure S4 from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

Key Points

No abstract yet

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Implication

Abstract

Discussion

Cite This Study

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