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May 1, 2024Open Access

Supplementary figure S3 from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

Tetsuo Tani Haritha Mathsyaraja Marco Campisi Zehua Li Koji Haratani Caroline G. Fahey Keiichi Ota Navin R. Mahadevan Yingxiao Shi Shin Saito Kei Mizuno Tran C. Thai Nobunari Sasaki Mizuki Homme Choudhury Fabliha B. Yusuf Adam Kashishian Jipsa Panchal Min Wang Benjamin Wolf Thanh U. Barbie Cloud P. Paweletz Prafulla C. Gokhale David Liu Ravindra Uppaluri Shunsuke Kitajima Jennifer Cain David A. Barbie

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Key Points

Inactivation of TREX1 unleashes STING–interferon signaling in cancer cells, actively driving an immune-mediated antitumor defense mechanism.
Supplementary figure S3 presents targeted molecular assays related to figure 3, detailing shifts across STING-dependent interferon pathways.
Experimental visualization of cancer cell phenotypes supports targeted TREX1 disruption, highlighting potential pathways for antitumor immunity.

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Implication

Experimental analysis reveals TREX1 inactivation unleashes STING-interferon signaling in cancer cells, highlighting enhanced antitumor immunity.

Abstract

Supplementary figureS3 shows the figures related to Figure 3.

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Cite This Study

Tani et al. (2024) studied this question.

synapsesocial.com/papers/68e6c4b3b6db6435876435e9 https://doi.org/10.1158/2159-8290.25729041

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary figure S3 from <i>TREX1</i> Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity2024
2Supplementary figure S2 from <i>TREX1</i> Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity2024
3Supplementary figure S2 from <i>TREX1</i> Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity2024
4Supplementary figure S4 from <i>TREX1</i> Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity2024
5Supplementary figure S4 from <i>TREX1</i> Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity2024

Supplementary figure S1 from <i>TREX1</i> Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity2024
Supplementary figure S1 from <i>TREX1</i> Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity2024
Supplementary Figure 1 from The Exonuclease TREX1 Constitutes an Innate Immune Checkpoint Limiting cGAS/STING-Mediated Antitumor Immunity2024