OR10-3 | Gender Disparities and Predictors of In-Patient Mortality with Takotsubo Cardiomyopathy – Insights from National Inpatient Sample

Takotsubo cardiomyopathy (TCM) is associated with significant gender disparities, such that it is more prevalent in females, but the clinical outcomes are worse for male patients. The goal of this study was to assess contemporary gender disparities in clinical outcomes of TCM hospitalizations and to determine predictors of male inpatient mortality. This was a retrospective analysis of adult hospitalizations for TCM in the U.S between 2016 – 2020. Multivariable Logistic regression was used to estimate Odds Ratio for inpatient mortality between the two genders. Univariable Cox regression was performed to identify predictors associated with inpatient mortality for male hospitalizations. All factors from the univariable analysis with p < 0.20 were included in a multivariable Cox regression model. A total of 199,920 patients with TCM were identified. Female patients had 50% lower risk of inpatient mortality compared to male patients (aOR 0.50, 95% CI 0.46- 0.55, p < 0.001). Older age, higher Charlson comorbidity index, history of intracranial hemorrhage, cardiac arrest, need for vasopressor agents, mechanical intubation, and cardiogenic shock without the use of temporary mechanical circulatory support (MCS) were associated with higher inpatient male mortality. Although TCM is more prevalent among females, gender disparities exist in the clinical outcomes of TCM patients. Cardiac arrest and cardiogenic shock without the use of temporary MCS were found to be the most significant predictors of male inpatient mortality. Cardiogenic shock with the use of temporary MCS did not lead to higher in-patient male mortality.