Higher mortality in male patients with Takotsubo cardiomyopathy appears to be related to higher complication rates

Background Mortality in male patients with Takotsubo cardiomyopathy appears to be double than the mortality rate of Women. The goal of this study was to evaluate whether the higher mortality is related to a higher complication rate in male adults Methods Using ICD-10 codes for Takotsubo cardiomyopathy, we evaluated differences in the occurrence of complications between Men and women. Results A total of 199,890 patients had a diagnosis of Takotsubo cardiomyopathy, with 4,770 male and 165,120 female patients. All major complications are significantly higher in men than women, despite multivariate adjustment for age and cardiovascular risk factors. Cardiogenic Shock: 9.88% vs 5.98% p<0.001, OR: 1.57, 1.43-1.73, Atrial Fibrillation: 23.96% vs 20.12%, p<0.001, OR:1.55, CI 1.45-1.66, Cardiac Arrest: 5.71% vs 2.94%, p<0.001, OR: 1.71, CI 1.51-1.94, Congestive Heart Failure: 39.52% vs 35.18% p <0.001, OR: 1.23, CI:1.16-1.30, Stroke: 7.45% vs 4.94%, p<0.001, OR: 1.51, CI:1.36-1.68). Conclusions All major cardiovascular complications are higher in men compared to women with a diagnosis of Takotsubo cardiomyopathy, as a plausible explanation for the higher mortality in men.