Why the study?
Recent studies have highlighted a mortality rate in Takotsubo syndrome similar to ACS, but the impact of gender differences on outcomes compared with ACS patients remained to be evaluated.
Does male gender impact the short-term clinical events and long-term prognosis in patients with Takotsubo Syndrome compared to Acute Coronary Syndrome?
Population
138 TTS patients and 300 ACS patients
Comparison
Male vs female TTS patients, compared with ACS patients
Design
Single-center comparative cohort study
Follow-up
5-year
Key result
Male gender was an independent predictor of 5-year mortality (HR 2.7; 95% CI 1.1-6.5; P=0.02), and male Takotsubo syndrome patients had significantly higher mortality than male ACS patients.
Authors
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Male Takotsubo patients face excess long-term mortality versus ACS; leaves open whether gender-tailored surveillance improves outcomes.
Cohort (n=438)
No
Does male gender impact the short-term clinical events and long-term prognosis in patients with Takotsubo Syndrome compared to Acute Coronary Syndrome?
Hazard Ratio: 2.7 (95% CI 1.1–6.5)
p-value: p=0.02
Male patients with Takotsubo syndrome experience more severe acute complications and have a poorer long-term prognosis compared to male patients with acute coronary syndrome.
Giannakopoulos et al. (2019) conducted a cohort in Takotsubo Syndrome and Acute Coronary Syndrome (n=438). Male gender vs. Female gender was evaluated on 5-year mortality (HR 2.7, 95% CI 1.1-6.5, p=0.02). Male gender was an independent predictor of 5-year mortality (HR 2.7; 95% CI 1.1-6.5; P=0.02), and male Takotsubo syndrome patients had significantly higher mortality than male ACS patients.
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