Why the study?
The prognostic significance of age in takotsubo syndrome remains debated, and evidence regarding male patients is limited.
Do older age and male sex independently predict higher in-hospital mortality in patients with takotsubo syndrome?
Population
13,585 patients with a first takotsubo syndrome episode undergoing coronary angiography in Japan
Comparison
Comparisons across age groups (≤50, 51–74, ≥75 years) and sex
Design
Retrospective nationwide registry-based cohort study
Key result
Male sex (OR 1.59) and older age (OR 1.32 per 5-year increase) were independently associated with higher in-hospital mortality in patients with takotsubo syndrome.
Authors
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May inform risk stratification by sex and age in takotsubo syndrome; hypothesis-generating pending prospective validation.
Cohort (n=13,585)
Yes
Do older age and male sex independently predict higher in-hospital mortality in patients with takotsubo syndrome?
Odds Ratio: 1.59 (95% CI 1.3–1.95)
p-value: p=<0.001
In patients with takotsubo syndrome, older age and male sex are independent predictors of in-hospital mortality and are associated with a higher burden of comorbidities and need for intensive care.
Hayashi et al. (2026) conducted a cohort in Takotsubo syndrome (n=13,585). Male sex and older age vs. Female sex and younger age was evaluated on In-hospital mortality (OR 1.59, 95% CI 1.30-1.95, p=<0.001). Male sex (OR 1.59) and older age (OR 1.32 per 5-year increase) were independently associated with higher in-hospital mortality in patients with takotsubo syndrome.