Key result
Male sex linked to ~3.9-fold higher in-hospital mortality in Takotsubo syndrome vs. females.
Why the study?
Gender differences in clinical characteristics and in-hospital outcomes of patients admitted with Takotsubo syndrome have not been adequately studied at a national scale.
Does male gender affect in-hospital outcomes in patients admitted with Takotsubo syndrome?
Observational (n=39,662)
Yes
Does male gender affect in-hospital outcomes in patients admitted with Takotsubo syndrome?
Although Takotsubo syndrome is predominantly seen in females, male patients experience significantly higher in-hospital morbidity and mortality.
Answers are grounded in this paper and cite their sources.
May warrant closer monitoring for males with Takotsubo syndrome; leaves open whether gender-specific strategies improve outcomes in prospective studies.
BACKGROUND: Takotsubo syndrome (TTS) is characterized by acute, transient systolic dysfunction of the left ventricle not attributed to coronary artery disease (CAD). HYPOTHESIS: There are differences in hospital outcomes in patients admitted with TTS based on their gender. METHODS: and Student's t test analyses, the P-value was calculated for differences among baseline characteristics of patients. Multivariate regression models were then created to adjust for potential confounders. RESULTS: A total of 39 662 admissions with TTS were identified, 91.7% female and 8.3% male with mean age of 66.5 and 61.6 years, respectively. The incidence of TTS increased progressively from 2006 to 2014. Female patients were more likely to have hypertension, hypothyroidism, or depression. Males were more likely to use tobacco, or have known CAD. Males had almost 4-fold higher probability of in-hospital mortality compared to females (3.7% vs 1.1%; P<0.001). Certain complications including cardiogenic shock, ventricular fibrillation/tachycardia, and acute kidney injury were more common in males. CONCLUSIONS: There are distinct gender differences in clinical characteristics of patients admitted with TTS. Although TTS is more common in females, it is associated with higher morbidity and mortality in males.
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Lemor et al. (2018) conducted an observational in Takotsubo syndrome (n=39,662). Male gender vs. Female gender was evaluated on In-hospital mortality (OR 3.89, 95% CI 2.41-6.24, p=<0.001). Male gender in patients with Takotsubo syndrome was associated with a significantly higher risk of in-hospital mortality compared to female gender (3.7% vs 1.1%; adjusted OR 3.89).
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