B-30 | Nationwide Assessment of Mortality Disparities For Patients With Preeclampsia and Covid During the First Year of the Pandemic

Racial disparities in outcomes for patients with both preeclampsia and COVID-19 have not been well studied. We analyzed the 2020 National Inpatient Sample (NIS) dataset to identify patients with a history of preeclampsia. We categorized them into two groups based on COVID-19 status. We employed logistic and linear regression analyses to identify associations, accounting for confounders. We set a 2-tailed p-value of 0.05 for significance. In 2020, we recorded 164,419 hospital admissions primarily diagnosed with preeclampsia. Of these, 2,153 (1.3%) tested positive for COVID-19. A difference in racial distribution was observed when comparing patients diagnosed with preeclampsia vs. those with preeclampsia and COVID-19. 50.2% of preeclampsia patients were White while 26.6% with preeclampsia and COVID, were White. Conversely, Black and Hispanic patients made up a larger proportion in the preeclampsia plus COVID group, with percentages at 26.4% and 38.1%, respectively, compared to 20.8% and 19.9% in the preeclampsia without COVID group (p<0.001). Patients with preeclampsia and COVID experienced a higher likelihood of in-hospital mortality (aOR 22.47, 95% CI 5.28 - 86.9), the need for ventilation (aOR 5.97, 95% CI 2.63 - 13.5), and vasopressor administration (aOR 4.49, 95% CI 1.49 - 13.5). This suggests the COVID pandemic disproportionately impacted Black and Hispanic patients and increased the risk of in-hospital mortality and the need for ventilation.