D-39 | Comparative Outcomes of Percutaneous Coronary Interventions in Patients with Chronic Total Occlusions: The Impact of Active Cancer

Percutaneous coronary interventions (PCI) for chronic total occlusions (CTO) present unique challenges in patients with active cancer due to their complex health profiles. This study aims to fill the gap in knowledge regarding the outcomes of CTO PCI in the cancer population, focusing on in-hospital mortality and readmission rates. National Inpatient Sample (2016-2020) were analyzed to identify patients with CTO who underwent PCI, with and without active cancer groups. Multivariate regression analysis determined the impact of cancer on in-hospital mortality (primary outcome) and readmission rates (secondary outcome). As shown in Table I, patients with active cancer were generally older (72 vs. 66 years, p <0.05) and had a distinct profile of comorbidities compared to non-cancer patients. In-hospital mortality was slightly higher in the cancer group (1.3% vs. 0.8%, p =0.33), and readmission rates were notably increased (9.3% vs. 7.1%, p =0.05). Secondary outcomes (Table II) revealed differences in post-procedural complications, acute kidney injury, and length of stay between the two groups. Patients with active cancer undergoing CTO PCI exhibit marginally higher in-hospital mortality and significantly higher readmission rates compared to those without cancer. These findings underscore the need for specialized care strategies and meticulous management in this high-risk group to improve procedural outcomes and reduce hospital readmissions. Further studies are warranted to refine patient care protocols and enhance overall treatment outcomes for this vulnerable population.