Chiral induction and amplification of achiral molecules induced by chiral compounds in solid matrices

To demonstrate chiral induction and amplification in the solid state, we investigated co-crystals prepared from (S)- or (R)-1-phenylethylamine and achiral biphenyl-4-carboxylic acid by solvent-free crystallization. The chiroptical and optical properties of the co-crystals were characterized by circular dichroism spectroscopy, Fourier transform infrared spectroscopy, and time-dependent density functional theory calculations, revealing chiral induction, and amplification in the solid phase.