Effect of Enamel Matrix Protein Derivative (Emd) as an Adjunct to Xenograft Compared to Xenograft Alone in the Treatment of Intrabony Defects in Subjects With Chronic Periodontitis: A Systematic Review.

Background: Enamel matrix derivative (EMD) has been widely used in periodontal regenerative treatment and the xenograft biomaterials show good biocompatibility and osteoconductivity of demineralized bovine bone matrix. So, to evaluate the improvement in clinical outcomes when Enamel Matrix Protein Derivative is used as an adjunct to Bovine-Derived Xenograft in intrabony defects of chronic periodontitis patients. Material And Methodology: In this systematic review, randomized controlled trials in subjects with periodontitis in the age group of 25-70 years were considered. An electronic search was made in PubMed, Google Scholar, and EMBASE databases. Studies concerning the use of a combination of enamel matrix derivative (EMD) and Xenograft compared with xenografts alone in periodontitis treatment were selected. Result: 4 studies were included in quantitative analysis after screening by two reviewers. Randomized controlled trials have indicated a signicantly higher pocket reduction and clinical attachment level gain after the application of enamel matrix derivative (EMD) and Xenograft compared with xenografts alone. Conclusion: The use of enamel matrix derivative (EMD) as an adjunct to Xenograft provides signicant results as compared to xenograft alone in intrabony defects of chronic periodontitis patients.