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May 1, 2024Nephrology Dialysis TransplantationOpen Access

#3036 The influence of first renal graft on second graft rejection and survival: the importance of revisiting histocompatibility and clinical outcomes

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Authors

RLRita LealHospitais da Universidade de CoimbraAMAntónio MartinhoUniversity of LisbonJVJoão VendaHospitais da Universidade de Coimbra

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Implication

Retrospective longitudinal study shows first graft nephrectomy and mismatch load increase acute rejection in second kidney recipients, highlighting the impact of prior histocompatibility.

Key Points

  • First graft nephrectomy and high initial HLA mismatch load significantly increase the risk of acute rejection and reduce long-term allograft survival in kidney retransplantation.
  • An odds ratio of 3.9 marked higher acute rejection following prior nephrectomy, and post-transplant donor specific antibodies emerged in 58% of these affected retransplant recipients.
  • Retrospective, longitudinal study of 114 retransplant cases reveals that previous immunological sensitization impairs graft survival, highlighting the need to revisit histocompatibility.

Cite This Study

Leal et al. (2024) studied this question.

synapsesocial.com/papers/68e6c82cb6db643587646599https://doi.org/10.1093/ndt/gfae069.1027
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PROGNOSTIC INDICES TO PREDICT SURVIVAL OF FIRST AND SECOND RENAL ALLOGRAFTS1991 · 37 citations
  2. 2THE INFLUENCE OF HISTOCOMPATIBILITY ON GRAFT REJECTION AND GRAFT SURVIVAL WITHIN A SINGLE CENTER POPULATION OF HEART TRANSPLANT RECIPIENTS1999 · 18 citations
  3. 3Prognosis of renal re-transplantation for chronic graft failure2026
  4. 4Influence Of Hla Matching On Rejections And Short - And Long-Term Primary Cadaveric Allograft Survival1993 · 46 citations
  5. 5Long-Term Graft and Patient Survival After Re-Transplantation2024