Key result
Well-matched HLA A, B cadaveric kidneys did not significantly improve 7-year graft survival (61% vs 63%) or reduce rejection episodes compared to poorly matched kidneys.
Why the study?
Does well-matched HLA matching improve graft survival and reduce rejection episodes in primary cadaveric renal allograft recipients?
Population
683 cyclosporine-prednisone-treated primary cadaveric renal allograft recipients at a single center
Comparison
Well-matched HLA A, B kidneys or well-matched… vs Poorly matched HLA A, B or poorly matched HLA-DR
Design
Cohort
Follow-up
7 years
Authors
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HLA A,B matching should not guide allocation in cyclosporine-treated recipients; leaves open its value under modern immunosuppression.
Cohort (n=683)
No
Does well-matched HLA matching improve graft survival and reduce rejection episodes in primary cadaveric renal allograft recipients?
Absolute Event Rate: 61% vs 63%
In cyclosporine-prednisone-treated primary cadaveric renal allograft recipients, HLA matching did not significantly improve short- or long-term graft survival or reduce rejection episodes.
Kerman et al. (1993) conducted a cohort in Primary cadaveric renal allograft recipients (n=683). Well-matched HLA A, B kidneys (≤ 2 mismatches) vs. Poorly matched HLA A, B kidneys (> 2 mismatches) was evaluated on 7-year graft survival. Well-matched HLA A, B cadaveric kidneys did not significantly improve 7-year graft survival (61% vs 63%) or reduce rejection episodes compared to poorly matched kidneys.
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