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March 1, 1994Transplantation

The Relationship Among Donor-Recipient Hla Mismatches, Rejection, and Death From Coronary Artery Disease in Cardiac Transplant Recipients1

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Why the study?

Does donor-recipient HLA matching improve survival, reduce rejection, or prevent death from coronary artery disease in cardiac transplant recipients?

Population

448 cyclosporine-treated heart transplant recipients

Comparison

Well-matched donor-recipient HLA vs Poorly matched donor-recipient HLA

Design

Cohort

Follow-up

up to 5 years

Authors

RKRonald H. KermanBaylor College of MedicinePKPamela KimballBrown UniversitySSSCOTT SCHEINEN

Discussion

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Implication

Does not support HLA matching for survival benefit in heart transplant allocation; leaves open prospective trials on rejection reduction.

Structured PICO

Does donor-recipient HLA matching improve survival, reduce rejection, or prevent death from coronary artery disease in cardiac transplant recipients?

P
Population
448 cyclosporine-treated heart transplant recipients
I
Intervention
Well-matched donor-recipient HLA (≤ 2 A, B, or 0-1 DR mismatches)
C
Comparator
Poorly matched donor-recipient HLA (> 2 A, B, or 2 DR mismatches)
O
Outcome
Patient survival, rejection, and death from coronary artery disease (CAD)hard clinical

Donor-recipient HLA matching in heart transplant recipients does not significantly improve survival but is associated with fewer rejection episodes.

Cite This Study

Kerman et al. (1994) studied this question.

synapsesocial.com/papers/6a815bfcfd865eccc666060ehttps://doi.org/10.1097/00007890-199403270-00020

Topics

Heart transplantation
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1HLA match and other immunological parameters in relation to survival, rejection severity, and accelerated coronary artery disease after heart transplant1990 · 15 citations
  2. 2Influence Of Hla Matching On Rejections And Short - And Long-Term Primary Cadaveric Allograft Survival1993 · 46 citations
  3. 3Role of HLA matching and donor specific antibody development in long-term survival, acute rejection and cardiac allograft vasculopathy2024 · 9 citations
  4. 4HUMAN LEUKOCYTE ANTIGEN COMPATIBILITY IN HEART TRANSPLANTATION1997 · 19 citations
  5. 5THE INFLUENCE OF HISTOCOMPATIBILITY ON GRAFT REJECTION AND GRAFT SURVIVAL WITHIN A SINGLE CENTER POPULATION OF HEART TRANSPLANT RECIPIENTS1999 · 18 citations