Key result
Better HLA matching and lower T-cell PRA are linked to improved survival and less severe rejection.
Why the study?
Do donor/recipient HLA compatibility and other immunological parameters affect survival, rejection severity, and accelerated coronary artery disease after heart transplant?
Population
113 consecutive cardiac transplant patients who were at least 3 months post-transplant
Design
Cohort
Follow-up
At least 3 months (subset followed to 1 year)
Authors
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May inform donor selection to reduce rejection risk; hypothesis-generating for randomized trials on HLA matching.
Cohort (n=113)
Do donor/recipient HLA compatibility and other immunological parameters affect survival, rejection severity, and accelerated coronary artery disease after heart transplant?
Better HLA matching and favorable pre-transplant immunological parameters improve survival and reduce rejection severity in heart transplant recipients, while post-transplant antilymphocyte antibodies predict coronary artery disease and mortality.
Ballantyne et al. (1990) conducted a cohort in Cardiac transplant (n=113). Donor/recipient HLA compatibility and immunological parameters vs. Poor HLA match and higher immunological risk parameters was evaluated on Graft/patient survival, severity of rejection episodes, and development of coronary artery disease. Better donor/recipient HLA matches and lower pre-transplant T-cell PRA were associated with improved graft/patient survival and less severe rejection episodes.
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