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January 1, 2013Journal of TransplantationOpen Access

Occurrence of Fatal and Nonfatal Adverse Outcomes after Heart Transplantation in Patients with Pretransplant Noncytotoxic HLA Antibodies

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Why the study?

Does the presence of pretransplant noncytotoxic HLA antibodies predict fatal and nonfatal adverse outcomes in heart transplant recipients?

Population

173 consecutive heart transplant recipients testing negative for cytotoxic HLA antibodies and for…

Comparison

Presence of pretransplant noncytotoxic HLA… vs Absence of pretransplant noncytotoxic HLA…

Design

Cohort

Authors

LPLuciano PotenaHeart Failure & TransplantABAndrea BontadiniAzienda Ospedaliera Santa Maria Degli AngeliSIS. IannelliIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola

Discussion

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Implication

Pretransplant HLA antibodies were associated with doubled mortality after heart transplant; leaves open whether screening or desensitization improves outcomes.

Structured PICO

Does the presence of pretransplant noncytotoxic HLA antibodies predict fatal and nonfatal adverse outcomes in heart transplant recipients?

P
Population
173 consecutive heart transplant recipients testing negative for cytotoxic HLA antibodies and for prospective crossmatch, mean age 52 ± 13 years, 16% female, 47% ischemic etiology.
I
Intervention
Presence of pretransplant noncytotoxic HLA antibodies detected by Luminex-based screening
C
Comparator
Absence of pretransplant noncytotoxic HLA antibodies
O
Outcome
Survival/mortalityhard clinical

Pretransplant noncytotoxic HLA antibodies detected by Luminex screening predict increased mortality, early graft failure, and rejection in heart transplant recipients.

Cite This Study

Potena et al. (2013) studied this question.

synapsesocial.com/papers/6a8cf6163022f0548e71bcb1https://doi.org/10.1155/2013/519680
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preformed IgG Antibodies Against Major Histocompatibility Complex Class II Antigens Are Major Risk Factors for High-grade Cellular Rejection in Recipients of Heart Transplantation1998 · 153 citations
  2. 2Significance of the Positive Crossmatch Test in Kidney Transplantation1969 · 1,514 citations
  3. 3A Survey of Current Practice for Antibody-Mediated Rejection in Heart Transplantation2013 · 80 citations