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March 1, 1991Transplantation

The Role of Anti-Hla Antibodies in Heart Transplantation

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Why the study?

Does the formation of anti-HLA antibodies reduce survival in heart allograft recipients?

Population

107 heart allograft recipients

Comparison

Formation of anti-HLA antibodies vs Recipients who developed no anti-HLA antibodies

Design

Cohort

Follow-up

4 years

Authors

NSNicole Suciu‐FocaColumbia University Irving Medical CenterERElaine ReedSt. Luke's-Roosevelt Hospital CenterCMCharles C. MarboeCross-Cutting Cardiology

Discussion

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Implication

Anti-HLA antibody formation was associated with lower survival after heart transplant; hypothesis-generating and requires prospective validation before guiding care.

Structured PICO

Does the formation of anti-HLA antibodies reduce survival in heart allograft recipients?

P
Population
107 heart allograft recipients
I
Intervention
Formation of anti-HLA antibodies
C
Comparator
Recipients who developed no anti-HLA antibodies (nonproducers)
O
Outcome
Actuarial survival at 4 yearshard clinical

The formation of anti-HLA antibodies in heart transplant recipients is associated with significantly lower 4-year survival, suggesting a key role in chronic rejection.

Cite This Study

Suciu‐Foca et al. (1991) studied this question.

synapsesocial.com/papers/6a8cf68e58db4b48d896813fhttps://doi.org/10.1097/00007890-199103000-00033

Topics

Heart transplantation
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PREDICTIVE SIGNIFICANCE OF ANTI-HLA AUTOANTIBODIES IN HEART TRANSPLANT RECIPIENTS2014 · 2 citations
  2. 2Heart Transplantation and Anti-HLA antibodY: Myocardial Dysfunction and Prognosis - HeartLAy Study2023 · 6 citations
  3. 3Donor‐specific HLA antibodies after transplantation are associated with deterioration in cardiac function1996 · 31 citations
  4. 4Role of HLA matching and donor specific antibody development in long-term survival, acute rejection and cardiac allograft vasculopathy2024 · 9 citations
  5. 5Occurrence of Fatal and Nonfatal Adverse Outcomes after Heart Transplantation in Patients with Pretransplant Noncytotoxic HLA Antibodies2013 · 16 citations