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May 14, 2014Russian Journal of Transplantology and Artificial OrgansOpen Access

Predictive Significance of Anti-Hla Autoantibodies in Heart Transplant Recipients

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Why the study?

Does the presence of preformed anti-HLA antibodies increase the risk of antibody-mediated rejection and cardiac allograft vasculopathy in heart transplant recipients?

Population

140 heart transplant recipients (106 with dilated cardiomyopathy, 34 with ischemic cardiomyopathy)

Comparison

Preformed anti-HLA antibodies positive vs Preformed anti-HLA antibodies negative

Design

Cohort

Follow-up

up to 3 years

Authors

ОSО. P. ShevchenkoSechenov UniversityТХТ. А. ХалилулинSechenov UniversityГОГ. А. ОлефиренкоV.I.Shumakov Federal Research Center of Transplantology and Artificial Organs

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Implication

Heightens AMR and CAV surveillance in anti-HLA positive recipients; leaves open whether desensitization improves graft outcomes.

Structured PICO

Does the presence of preformed anti-HLA antibodies increase the risk of antibody-mediated rejection and cardiac allograft vasculopathy in heart transplant recipients?

P
Population
140 heart transplant recipients (106 with dilated cardiomyopathy, 34 with ischemic cardiomyopathy)
I
Intervention
Preformed anti-HLA antibodies positive (determined before transplantation by ELISA)
C
Comparator
Preformed anti-HLA antibodies negative
O
Outcome
Antibody-mediated rejection (AMR) and cardiac allograft vasculopathy (CAV)hard clinical

The presence of preformed anti-HLA antibodies in heart transplant candidates significantly increases the risk of antibody-mediated rejection and cardiac allograft vasculopathy.

Cite This Study

Shevchenko et al. (2014) studied this question.

synapsesocial.com/papers/6a6fdde7e71d69abee083ea2https://doi.org/10.15825/1995-1191-2013-4-16-23
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1De Novo Donor HLA-Specific Antibodies after Heart Transplantation Are an Independent Predictor of Poor Patient Survival2011 · 287 citations
  2. 2Consensus Guidelines on the Testing and Clinical Management Issues Associated With HLA and Non-HLA Antibodies in Transplantation2012 · 781 citations
  3. 3Significance of the Positive Crossmatch Test in Kidney Transplantation1969 · 1,514 citations