AB112. SOH24AB_199. Soft tissue sarcoma: experience of a national tertiary referral centre over a ten-year period

Background: The incidence and demographic profile of patients with soft tissue sarcomas of the torso (STSt) in Ireland is poorly delineated in the literature to date. This study investigates the epidemiology of STSt within a prominent national tertiary referral network. Analysing patient demographics, histological subtypes, and treatment modalities, this research aims to enhance our understanding of STSt prevalence and management trends, particular after international recent paradigm shifts in care. Methods: A retrospective cohort study of a cancer database at a St Vincent's Sarcoma Ireland Network (SSIN) referral centre was performed. Demographic data, histopathological reports, and treatment regimens were analysed. Descriptive statistics and regression models were employed to elucidate epidemiological and treatment patterns. Results: All patients referred to 2018 with a sarcomatoid diagnosis were included. In total, 90 patients, made up of 56% females and 44% males with a median age of 60 were included. Across all referrals, 63% were patients living outside of Dublin spanning 17 counties. The most common tumour sites were retroperitoneal (39%), abdominopelvic (26%) and groin (14%). Histological subtypes included leiomyosarcoma (19%), well-differentiated liposarcoma (10%), dedifferentiated liposarcoma (8%). Neoadjuvant treatment was given to 17% of patients independent of age (mean difference <1 year, P=0.81). Tumours were deemed resectable in 90% of cases. Of those resected, 97.8% achieved R0/1 margins with a mean tumour size of 11.5 cm (range: 2.1–39 cm; resected versus non resected, P=0.12). Minimum follow-up time recorded for patients was 18 months. Of this cohort, 48% are alive without disease. Conclusions: The study highlights treatment trends are based on disease factors and not size (technical) or age (patient factors). Survival trends and treatment approaches are favourably compared to international standards.