Background: Postoperative recurrence rates in solid cancers remain high at 20–66% even with curative resection. Prolonged surgically-induced inflammation can trigger an immunosuppressive cascade supportive of tumour progression and recurrence. By preventing excessive inflammation, immunosuppression is reduced. Potential cytokine targets include proinflammatory interleukin (IL)-6 and IL-8, produced by fibroblasts following tissue damage. This study evaluates the effect of 1,4,5-oxathiazinane-4,4-dioxide (OTD) on IL-6 and IL-8 production in human dermal fibroblasts (HDFs).
No takes yet. Share an insight, caveat, or question.
O’Callaghan et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: