Effect of Tolperisone a Muscle Relaxant in the Management of Musculoskeletal Disorders in the Population of Central India

Background: Drugs like skeletal muscle relaxants produce reversible skeletal muscle relaxation.Skeletal muscle function and muscle tone are affected by muscle relaxants.Tolperisone a piperidine derivative is a centrally-acting skeletal muscle relaxant with membrane-stabilizing properties and under clinical use for decades.It provides more than 75% improvement in spastic disorders.This study aims to be carried out to observe the effect of Tolperisone as a muscle relaxant in various musculoskeletal disorders and to find out any adverse effects it produces.Methods: In the present clinical study, 299 patients, aged between 21 and 65 years with various kinds of musculoskeletal disorders participated.Before enrollment of the cases, musculoskeletal disorders were diagnosed by clinical examinations and various investigations such as X-Ray, MRI, RA factor, Uric acid, anti-CCP, CRP, ESR, etc. depending upon the history and clinical examinations.Confirmed cases of musculoskeletal disorders were treated by giving Tolperisone 150 mg thrice daily for 5 to 10 days.After 5-10 days, a clinical examination was done and a self-administered questionnaire was given for subjective responses.Results: Based on clinical examinations and subjective response, all 299 cases got symptomatic relief from the signs and symptoms.The range of relief was between 80-100%.No adverse effect was reported except in one case where metallic taste was reported. Conclusion:It can be concluded that Tolperisone at the dose of 150 mg is a good and safe muscle relaxant for various musculoskeletal disorders.