April 30, 2024Heart

Incidence and risk factors for development of left ventricular hypertrophy in Fabry disease

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Authors

EMEmanuele MondaHeart Failure / Cardiomyopathy ABAthanasios BakalakosHeart Failure / Cardiomyopathy RLRobin LachmannNational Hospital for Neurology and Neurosurgery

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Implication

Observational cohort study reveals left ventricular hypertrophy in a quarter of Fabry disease patients over nine years, highlighting male sex, older age, and abnormal ECG as key predictors.

Key Points

Left ventricular hypertrophy developed in nearly one-quarter of adults with Fabry disease, reaching an estimated cumulative incidence of 45.0% across fifteen years of clinical follow-up.
An abnormal ECG increased risk of hypertrophy more than threefold with hazard ratio 3.10, alongside male sex and progressive increases in left ventricular mass index over time.
Prospective observational cohort study of 214 adults followed in a specialist cardiomyopathy centre highlights that multivariable analysis identifies high-risk individuals for monitoring.

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Monda et al. (2024) studied this question.

synapsesocial.com/papers/68e6ca92b6db643587648eb4 https://doi.org/10.1136/heartjnl-2023-323783

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Implication

Observational cohort study reveals left ventricular hypertrophy in a quarter of Fabry disease patients over nine years, highlighting male sex, older age, and abnormal ECG as key predictors.

Incidence and risk factors for development of left ventricular hypertrophy in Fabry disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Incidence and risk factors for development of left ventricular hypertrophy in Fabry disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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