Evaluation of Nootropic Activity of Guggul Against Scopolamine Induced Memory Impairment in Albino Wistar Rats

Background: Guggul is a natural gum resin used as traditional Indian medicine.Objective: The objective of the present study is to evaluate the nootropic activity of guggul oleo gum resin against scopolamine induced memory impairment in albino wistar rats.Methods: In this study 25 albino wistar rats were randomly selected and divided in to 5 groups.Each group consists of 5 animals -Group: 1(Control), Group: 2(negative control scopolamine 20mg/kg I.P), Group: 3(standard Donepazil 5mg/kg P.O), Group: 4&5 different versus of extract AECW (50mg&100mg/kg P.O).Memory impairment was induced with scopolamine at a single dose of 20mg/kg body weight i.p to the groups expect control group at 7th day estimation of behavioral studies was carried out by the Y-Maze, Labyrinth Maze, Elevated Plus Maze.Results: AECW treated groups shows transfer latency similar to the donepezil treated groups.Scopolamine treated groups show more transfer latency when compared with donepazil treated groups. Conclusion:The AECW has shown significant effect at a dose of 50mg/kg which is similar to standard donepazil 5mg/kg due to presence of phytochemical constituents like flavonoids, tannins,