Development of an eco-friendly voltammetric approach for determination of anti-coagulant drug edoxaban by highly sensitive iron oxide prob

Abstract Edoxaban tosylate monohydrate (EDTM) is a direct oral anticoagulant drug that has recently been incorporated into most COVID-19 treatment protocols as either prophylaxis or therapy because it is effective and safe in the treatment of coagulopathy that is life-threatening in post-COVID-19. So, we developed a new, eco-friendly, sensitive differential pulse voltammetric method using 10.0% iron oxide nanoparticles as a modified carbon paste electrode (10.0% Fe₂O₃/CPE) in 0.1M borate buffer pH 10.0 as a supporting electrolyte. The electrochemical behavior of EDTM confirmed irreversible diffusion-controlled oxidation. Our modified sensor (10.0% Fe₂O₃/CPE) showed high sensitivity with a linear relationship between the peak current and EDTM concentration over the concentration range of 200–3500 ng/mL with a correlation coefficient of 0.9995, a limit of detection of 60 ng/mL, and a limit of quantification of 100 ng/mL. Our suggested method was successfully applied in bulk, pharmaceutical dosage form, spiked human plasma, and urine with high recovery 100.81% ±1.48 The results were statistically compared with the reported method and found to be in good agreement with it.