Review demonstrates circadian disruption elevates cardiovascular and metabolic disorder risks in humans, highlighting the need for circadian-informed diagnostic strategies.
Key Points
Disruption of human circadian rhythms is linked to cardiovascular disease, and circadian misalignment consistently impairs systemic glucose tolerance.
Review of clinical trials indicates that circadian system disturbance from shift work elevates the observed risk of type 2 diabetes mellitus in adult populations.
Highlights clinical opportunities to target the suprachiasmatic nucleus and peripheral clocks, supporting novel diagnostic strategies for cardio-metabolic disease.